CRISP1 as a novel CatSper regulator that modulates sperm motility and orientation during fertilization
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چکیده
منابع مشابه
CRISP1 as a novel CatSper regulator that modulates sperm motility and orientation during fertilization
Ca(2+)-dependent mechanisms are critical for successful completion of fertilization. Here, we demonstrate that CRISP1, a sperm protein involved in mammalian fertilization, is also present in the female gamete and capable of modulating key sperm Ca(2+) channels. Specifically, we show that CRISP1 is expressed by the cumulus cells that surround the egg and that fertilization of cumulus-oocyte comp...
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The cation channel of sperm (CatSper) comprises four transmembrane subunits specifically expressed in human, equine, murine and ovine spermatozoa, apparently implicated in capacitation, hyperactivation and acrosome exocytosis. Western blotting and immunocytochemistry showed hereby that CatSper subunits are also present in boar spermatozoa, primarily over the sperm neck, tail and cytoplasmic dro...
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متن کاملAll four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility.
Mammalian spermatozoa become motile at ejaculation, but before they can fertilize the egg, they must acquire more thrust to penetrate the cumulus and zona pellucida. The forceful asymmetric motion of hyperactivated spermatozoa requires Ca2+ entry into the sperm tail by an alkalinization-activated voltage-sensitive Ca2+-selective current (ICatSper). Hyperactivation requires CatSper1 and CatSper2...
متن کاملHyperactivated sperm motility driven by CatSper2 is required for fertilization.
Elevations of sperm Ca2+ seem to be responsible for an asymmetric form of motility called hyperactivation, which is first seen near the time of fertilization. The mechanism by which intracellular Ca2+ concentrations increase remains unknown despite considerable investigation. Although several prototypical voltage-gated calcium channels are present in spermatozoa, they are not essential for moti...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2015
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201412041